Climax Laboratories, Inc.
With challenge comes innovation, with experience comes efficiency.
ADME/Pharmacokinetics
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In vitro metabolic stability (S9, microsomes, CYP450 isoforms or hepatocytes)
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In vitro CYP inhibition (IC50 and Ki)
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In vitro CYP reaction phenotyping (microsomes, S9, or recombinant CYPs)
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Metabolic profiling and identification (in vitro and in vivo)
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Compartmental and non-compartmental PK analysis
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PK/PD modeling and simulation
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In-life rodent studies
Consulting
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Bioanalytical and analytical chemistry
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PK and metabolism
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GLP compliance and regulation
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Method development and validation with HPLC/UV or LC/MS/MS
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Quantification and identification of small or large molecules in biological samples
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Chemical stability and purity analysis of test compounds
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In vitro stability of test compounds in biological matrices
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Protein binding of test compounds in biological matrices
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Characterization and identification of chemical impurities
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Bioanalysis of clinical biomarkers
Bioanalytical/Analytical Chemistry
